NSW Police have charged 89 people, and 72 drivers returned positive drug tests, during a high-visibility road traffic operation in Sydney, the Illawarra and South Coast.

Operation Fume ran on 6pm on Saturday until 4am on Sunday, targeting drug and alcohol-driving offences, and general road compliance across south-eastern Sydney, and the Wollongong, Lake Illawarra, Hume, South Coast and Monaro Police Districts.

The operation involved Traffic and Highway Patrol Command officers conducting mobile and stationary drug and alcohol testing at locations of serious injury or fatal crashes.

There were 4850 breath tests conducted with 25 positive breath tests, as well as 524 roadside drug tests conducted with 72 positive drugs tests, including cannabis, cocaine and meth.

Police issued 310 traffic infringements, 52 speeding infringements and apprehended 43 unauthorised drivers (14 suspended drivers, 25 unlicensed drivers and four disqualified drivers).

About 12:25pm on Sunday, Traffic and Highway Patrol officers were conducting random breath test on the southbound lane of Five Island Road, Cringila, when a motorcyclist allegedly drove past the site with no registration plates, before accelerating at speed above the signposted 80km/h.

A police officer followed and initiated a pursuit after the car failed to stop at the Northcliffe Drive intersection.

Police will allege the bike reached 180km/h in a 70km/h sign-posted zone.

As the motorcyclist approached Windang Road, he stopped and was arrested. The rider was subjected to a breath and drug test, both returned a negative reading.

Police inspected the motorcycle and observed no registration plate or rear indicator. Further checks allegedly revealed the rider to have his license suspended.

The 20-year-old was taken to Lake Illawarra Police Station and charged with police pursuit - not stop - drive at speed, drive motor vehicle while licence suspended and use registrable vehicle not display authorised number-plates

His bike was seized for three months. He was granted conditional bail to appear in Kiama Local Court on Monday 4 August.

About 1.50am on Sunday, a car was stopped on Douglas Street, Nowra for the purpose of a random breath test. The 21-year-old female driver allegedly returned a positive drug test.

Checks allegedly found the driver was a suspended learner driver. She was taken to Nowra Police Station and charged with drive motor vehicle while license suspended and fail or refuse to comply with prohibition or requirement.

She was granted conditional bail to appear in Nowra Local Court on Tuesday 15 July.